Anti-Inflammatory Effect of Sage (Salvia Officinalis) Extracts ABSTRACT on Oral Health

Muntaha Fawzi, Zena Kamel, Sabah Farhan


The aim of the study is to show the anti-inflammatory effect of sage (Salvia officinalis) extract as mouthwash on treating the infect- ed gums (gingivitis) and mouth ulcers (minor aphthous ulceration).
Methods and materials: sixty (60) patients (50% female and 50% male) 30 patients had RAU (minor aphthous ulceration) according to clinical presentation and 30 patients had gingivitis according to gingival index of loe and Silness. Sage mouthwash was extracted from the plant Salvia officinalis. The patients of the study group were demonstrated to how they made the mouth wash. Patients with minor aphthous ulceration of study and control group were included in the post-treatment daily observations of the ulcer on [first, third and sixth day] and we looked for pain relief, reduction of intensity of pain, reduction in size of ulcers, and complete healing.

Results: Analysis of gingival scores by gingival index of loe and silness of sage mouthwash individually showed a statistically highly significant improvement and healing of gingivitis (decreased mean value) from the first day to the sixth day. Analysis of gingival scores by gingival index of loe and silness of normal saline mouthwash showed a statistically significant results from the first day to the sixth day but there was no complete healing. Minor aphthous signs and symptoms of the study group in comparison with control group showed a statistically significant improvement in daily observations.

Conclusions: Sage extract was found to be effective as anti-inflammatory product against gingival inflammation and mouth ulcers and present study confirmed the efficacy of the plant. 


Sage; Salvia officinalis; Gingivitis, RAU; herbal extracts.

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