Anti-Inflammatory Effect of Sage (Salvia Officinalis) Extracts ABSTRACT on Oral Health

Muntaha Fawzi, Zena Kamel, Sabah Farhan

Abstract


The aim of the study is to show the anti-inflammatory effect of sage (Salvia officinalis) extract as mouthwash on treating the infect- ed gums (gingivitis) and mouth ulcers (minor aphthous ulceration).
Methods and materials: sixty (60) patients (50% female and 50% male) 30 patients had RAU (minor aphthous ulceration) according to clinical presentation and 30 patients had gingivitis according to gingival index of loe and Silness. Sage mouthwash was extracted from the plant Salvia officinalis. The patients of the study group were demonstrated to how they made the mouth wash. Patients with minor aphthous ulceration of study and control group were included in the post-treatment daily observations of the ulcer on [first, third and sixth day] and we looked for pain relief, reduction of intensity of pain, reduction in size of ulcers, and complete healing.

Results: Analysis of gingival scores by gingival index of loe and silness of sage mouthwash individually showed a statistically highly significant improvement and healing of gingivitis (decreased mean value) from the first day to the sixth day. Analysis of gingival scores by gingival index of loe and silness of normal saline mouthwash showed a statistically significant results from the first day to the sixth day but there was no complete healing. Minor aphthous signs and symptoms of the study group in comparison with control group showed a statistically significant improvement in daily observations.

Conclusions: Sage extract was found to be effective as anti-inflammatory product against gingival inflammation and mouth ulcers and present study confirmed the efficacy of the plant. 


Keywords


Sage; Salvia officinalis; Gingivitis, RAU; herbal extracts.

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References


Badria FA and Zidan OA. Natural products for dental caries prevention. Journal of Medicinal Food, 2004; 7)3(: 38-84. 2. Malhotra R, Grover V, Kapoor A and Saxena D. Comparison of the effectiveness of a commercially available herbal mouth rinse with chlorhexidine gluconate at the clinical and patient level. Journal of Indian Society of Periodontology,

; 15)4(:349-52.

Salam et al., Antimicrobial activity of medicinal plant for oral

health and hygiene. International Journal of Natural and

Social Sciences 2, 2015; 01-12 2.

Scully C, Porter S. Oral mucosal disease: recurrent aphthous

stomatitis. Br J Oral Maxillofac Surg. 2008; 46)3(:198–206. 5. Greenbery M, Glick M. Burket’s Oral Medicine Diagnosis and Treatment. 11th ed. Hamilton: BC Decker; 2008:63–65. 6. Porter SR, Hegarty A, Kaliakatsou F, Hodgson TA, Scully C. Recurrent aphthous stomatitis. Clin Dermatol. 2000;

5(:569–578.

Eisen D, Carrozzo M, Bagan Sebastian JV, Thongprasom

K, Number V. Oral lichen planus: clinical features and

management. Oral Dis. 2005; 11)6(:338–349. 8. McBride DR. Management of aphthous ulcers. Am Fam

Physician. 2000; 62)1(:149–154, 160.

Liu X, Guan X, Chen R, Hua H, Liu Y, Yan Z. Repurposing of

yunnan baiyao as an alternative therapy for minor recurrent aphthous stomatitis. Evid Based Complement Alternat Med. 2012:284620.

Haghpanah P, Moghadamnia AA, Zarghami A, Motallebnejad M. Muco-bioadhesive containing ginger officinale extract in the management of recurrent aphthous stomatitis: a randomized clinical study. Caspian J Intern Med. 2015;6)1(:3–

T. Nandhini et al. Comparison of the Effectiveness of a Commercially Available Herbal Mouth Rinse with Chlorhexidine Gluconate at the Clinical and Patient Level. J. Pharm. Sci. & Res. Vol. 7)8(, 2015, 595-597.

Samuels N, Grbic JT, Saffer AJ, Wexler ID, Williams RC.Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study. Compend Contin Educ Dent2012; 33: 204– 6, 208– 211.

Russo P, Frustaci A, Del Bufalo A, Fini M, Cesario A. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer’s disease: acetylcholinesterase inhibitors.Curr Med Chem2013;20: 976– 983.

Bozin B, Mimica-Dukic N, Samojlik I, Jovin E. Antimicrobial and antioxidant properties of rosemary and sage )Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae( essential oils. J Agric Food Chem2007; 55 )19(: 7879– 7885.

Jebashree HS, Kingsley SJ, Sathish ES, Devapriya D. Antimicrobial activity of few medicinal plants against clinically isolated human cariogenic pathogens-an in vitro study. ISRN Dent 2011; 2011: 541421.

Jayashankar S, Panagoda GJ, Amaratunga EA, Perera K, Rajapakse PS. A randomised double-blind placebo- controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables. Ceylon Med J 2011; 56: 5– 9.

Nadir M, Rasheed M, Sherwani SK, Kazmi SU, Ahmad VU. Chemical and antimicrobial studies on the essential oil from Salvia santolinifolia Boiss. Pak J Pharm Sci 2013; 26:

– 52.

Nikavar B, Abolhasani L, Izadpanah H. Alpha-amylase

inhibitory activities of six salvia species. Iran J Pharm

Res. 2008;7:297–303.

Itani WS, El-Banna SH, Hassan SB, Larsson RL, Bazarbachi

A, Gali-Mutasib HU. Anti colon cancer components from Lebanese sage )Salvia Libanotica( essential oil.Cancer Biol Ther. 2008;7:1765–73.

Ayatollahi A, Shojaii A, Kobarfard F, Mohammadzadeh M, Choudhary M. Two flavones from Salvia leriaefolia. Iran J Pharm Res. 2009;8:179–84.

Baranauskiene R, Dambrauskiene E, Venskutonis P. Influence of harvesting time on the yield and chemical composition of sage )Salvia officinalis L.( Foodbalt. 2011:105–9.

Kamatou P, Viljoen A, Steenkamp P. Antioxidant, anti- inflammatory activities and HPLC analysis of South African Salvia species. Food Chem. 2010;119:684–8.

Yurtseven S, Cetin M, Sengiil T, Sogut B. Effect of sage extract )Salvia officinalis( on growth performance, blood parameters, oxidative stress and DNA damage in partridges. S Afr J Anim Sci.2008;38:145–52.

Baricevic D, Sosa S, Loggia R, Tubaro A, Simonovska B, Krasna A, et al. Topical anti-inflammatory activity of Salvia officinalis L. leaves: The relevance of ursolic acid. J Ethnopharmacol. 2001;75:125–32.

Hamidpour, M., Hamidpour, R., Hamidpour, S., & Shahlari, M. Chemistry, Pharmacology, and Medicinal Property of Sage )Salvia( to Prevent and Cure Illnesses such as Obesity, Diabetes, Depression, Dementia, Lupus, Autism, Heart Disease, and Cancer. Journal of Traditional and Complementary Medicine, 2014; 4)2(, 82–88. http://doi. org/10.4103/2225-4110.130373.

Rami K, Li Z. Antimicrobial activity of essential oil of Salvia officinalis L. collected in Syria. Afr J Biotech. 2011;10:8397–402.

Walch S, Tinzoh L, Zimmerman B, Stuhlinger W, Lachenmeier D. Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. Front Pharmacol. 2011;2:29.[PMC free article] [PubMed]

Khan A, Najeeb-ur- Rahman, Alkharfy K, Gilani A. Antidiarrheal andantispasmodic activities of Salvia officinalis are mediated through activation of K + channels.J Bangladesh Pharmacol Soc.2011;6:111–6. 4

Loe H, Silness J. Periodontal disease in pregnancy I: prevalence and severity.Acta Odont Scan.1967;21:533–51 30. Rodrigues MR, Kanazawa LK, das Neves TL, da Silva CF, Horst H, Pizzolatti MG, et al. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. J

Ethnopharmacol 2012. ; 139: 519– 526.

Taheri JB, Azimi S, Rafieian N, Akhavan Zanjani H,herbs in

dentistry, International Dental Journal 2011; 61: 287–296. 32. Sookto T, Srithavaj T, Thaweboon S, Thaweboon B, Shrestha B, Nakazawa F. In vitro effects of Salvia officinalis L. essential oil on Candida albicans. Asian Pac J Trop Biomed.

May;3)5(:376-80.

Femiano F, Lanza A, Buonaiuto C, et al. Guidelines for

diagnosis and management of aphthous stomatitis. Pediatr

Infect Dis J. 2007;26)8(: 728–732.

Zheng LW, Hua H, Cheung LK. Traditional Chinese

medicine and oral diseases: today and tomorrow. Oral Dis. 2011;17)1(:7–12.

Li CL, He J, Li ZG, Zheng LW, Hua H. Effects of total glucosides of paeony for delaying onset of Sjogren’s syndrome: an animal study. J Craniomaxillofac Surg. 2013;41)7(:610–615.

Amanlou M, Babaee N, Saheb-Jamee M, Salehnia A, Farsam H, Tohidast Akrad Z. Efficacy of Satureja khuzistanica extract and its essential oil preparations in the management

of recurrent aphthous stomatitis. Daru. 2007;15)4(:231–

Ghalayani P, Zolfaghary B, Farhad AR, Tavangar A,

Soleymani B. The efficacy of Punica granatum extract in the management of recurrent aphthous stomatitis. J Res Pharm Pract. 2013;2)2(:88–92.




DOI: http://dx.doi.org/10.26477/idj.v39i1.111

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