Antiviral Activity of κ-carrageenan Gel on Herpes Simplex Type І, a Human Study: An Open-Label Clinical Trial

Hajer Ibrahem Abdulla, Marwan S.M. Al-Nimer, Aseel Jasim Ali


Aim of study This study aimed to study the possible application of carrageenan on the illnesses related to the oral cavity by studying
its effects in Viral infection presented with herpes simplex in human.(an-open label study)
Subjects,materials and methods In this study patients presented with oral herpes simplex lesions were treated with carrageenan
gel (0.9%)that was prepared .The gel was applied twice daily and the end-points of the study are the complete healing in absence
of any discomfort within a short period of treatment.
Results The results showed that two applications of κ-carrageenan per day accelerated the healing process within a short period
(1-2 days) without complications or disfigurement in all patients.
Conclusion κ –carrageenan besides ι-ond λ- carrageenan is useful in management of viral infection. κ –carrageenan is effective
against herpes simplex labialis .


κ – carrageenan, herpes simplex, antiviral activity, open label clinical trial.


Food and agriculture organization (FAO).training manual on

Gracilaria culture and seaweed processing in china .china:

Zhanjiang Fisheries College.1990

Chemical Safety Information from Intergovernmental

Organization (INCHEM).WHO Food Additive Series,

(2002). Safety Evaluation Of Certain Food Additive

and Contaminants,Carrageenan And Processed Eucheuma

Seaweed (Addendum). United Kingdom

Buck CB, Thompson CD, Roberts JN, Müller M, Douglas R

Lowy, SchillerJT(2006) . Carrageenan is a potent inhibitor

of papilloma virus infection: Plos Pathog 2(7):e69

Yamashita S, Sugita-Konishi Y, Shimizu M (2001).In vitro

bacteriostatic effects of dietary polysaccarid .Food Sci

Technol.Res 7(3):262-64.

Gonzalez M, Alarcon B, Carrasco L (1987). Polysaccharides

as antiviral agents: antiviral activity of carrageenan

.Antimicrob. Agents Chemother 31(9):1388-1393.

Zhou G,Sheng W, Yao W, Wang C(2006). Effect of low

molecular weight lambda carrageenan from chondrus

ocellatus on antitumor H22 activity of 5Fu. Pharmacol Res


Xiaoke Hu, Xiaolu Jiang , Eric Aubree PB (2006). In Vivo

antitumor Activity of l-carrageenan Oligosaccharides.

Pharmaceutical Biology [internet].[cited 2012 Nov.

:44(9):646-50. Available from :http://informahealthcare.


Reports of the Scientific Committee for Food(Thirty-fifth

series).Expressed on February 1996.pps 13-16.

Gheetha Arumugam(2012).Carrageenan-Induced Effect on

the Human Oral Epithelium and Microorganism :in vitro

J Van Houte , HV Jordan, R Laraway, R Kent, PM Soparkar

, PF DePaola.Association of the microbial flora of dental

plaque and saliva with human root –surface caries .J Dent

Res. 1990 August :69(8):1463-8.

Hand book of Hydrocolloids ,2000

Hand book of Pharmaceutical Excepient 2003

Ludwig M, Enzenhofer E, Schneider S, Rauch M, Bodenteich

A, Neumann K, Prieschl-Grassauer E, Grassauer A, Lion

T, Mueller CA.Efficacy of a carrageenan nasal spray in

patients with common cold: a randomized controlled trial.

Respir Res. 2013 Nov 13;14:124.

Fazekas T, Eickhoff P, Pruckner N, Vollnhofer G,

Fischmeister G, Diakos C, Rauch M, Verdianz M, Zoubek

A, Gadner H, et al.: Lessons learned from a doubleblind

randomised placebo-controlled study with a iotacarrageenan

nasal spray as medical device in children with

acute symptoms of common cold. BMC Complement

Altern Med 2012

Kenney J, Rodríguez A, Kizima L, Seidor S, Menon R,

Jean-Pierre N, Pugach P, Levendosky K, Derby N, Gettie A,

Blanchard J, Piatak M Jr, Lifson JD, Paglini G, Zydowsky

TM, Robbiani M, Fernández Romero JA. A modified zinc

acetate gel, a potential nonantiretroviral microbicide, is

safe and effective against simian-human immunodeficiency

virus and herpes simplex virus 2 infection in vivo.

Antimicrob Agents Chemother. 2013 Aug;57(8):4001-9.

Mateu CG, Recalde MP, Artuso MC, Hermida G, Linero

FN, Scolaro LA, Damonte EB, Pujol CA, Carlucci MJ.

Emergence of herpes simplex virus-1 syncytial variants

with altered virulence for mice after selection with a natural

carrageenan. Sex Transm Dis. 2011 Jun;38(6):555-61.

Chiu YH, Chan YL, Tsai LW, Li TL, Wu CJ. Prevention

of human enterovirus 71 infection by kappa carrageenan.

Antiviral Res. 2012 Aug;95(2):128-34.

Wang W, Zhang P, Hao C, Zhang XE, Cui ZQ, Guan HS.

In vitro inhibitory effect of carrageenan oligosaccharide on

influenza A H1N1 virus. Antiviral Res. 2011 Nov;92(2):237-



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