Evaluation of some trace elements levels in sera of patients with Angina Pectoris in Erbil city

Parween Abdulsamad Ismail, Araz Muhammad Yousif, Narmeen Abdulsamad Ismail


Background: Angina pectoris(AP) is one of the most prevalent diseases in developed countries and is becoming an area of increasing
concern in other parts of the world. Among the several causes of the disease alteration in the levels of trace elements are also
Objectives : This study was undertaken in order to investigate the serum trace elements level in patients with Angina pectoris
compared to healthy individuals, and to find whether there is any relationship between serum trace elements levels and patients
with Angina pectoris..
Methods: The study involved 50 patients with Angina pectoris(AP) for evaluation of these trace elements level ( Se Cu, Zn ,Fe& Cr
) as well as TG, TC and LDL-C and HDL as compared with 50 control subjects .
Results The results indicate that patients exhibited significant decrease in the serum of selinum(Se),zinc(Zn), copper(Cu),
chromium(Cr) and iron(Fe) level (p<0.001) as compared to the healthy controls. TG, TC and LDL-C were elevated in patients and
HDL-C was lower in our patients,
Conclusions. Deficiency or suboptimal levels of micronutriants( Se ,Cu, Zn ,Fe& Cr ) may play a role in the development of Angina
pectoris(AP). Measurement of serum trace elements level l might provide additional and useful laboratory test for the assessment
of the patients with Angina pectoris and oral trace elements may have a role in therapy.


Trace Elements; Angina pectoris


Toohey ML, Harris MA, Williams D, et al.Cardiovascular

disease risk factors are lower in African-American vegans

compared to lacto-ovo-vegetarians. JAm Coll Nutr.(2011);

: 425-34.

Underwood EJ..Trace elements in human and animal

nutrition. (2009).New York: Academic Press;

Sandstead H.H and Klevay C.M..“ Trace element nutrition

and human health’’ J.Nutr. (2010) 130:4835—4845.

Iskra M, Patelski J, Majewski W. Concentrations of calcium,

magnesium, zinc and copper in relation to free fatty acids

and cholesterol in serum of atherosclerotic men. J Trace

Elem Electrolytes Health Dis (2009);7:185–188.

Alfthan G, Pesonen E, Neuvonen PJ, et al. Relationships

between myocardial macrominerals and trace elementsand

luminal narrowing of coronary arteries in Finnish children.

(2010). J Trace Elem Electrolytes Health Dis:6:45-9.

Holner DA, Whiteside PJ. Introduction to atomic absorption

spectrophotometer(2008).. England: Pye –Unicam LTD;

Harris M, Taylor G.. Medical statistics made easy. (2008)

USA: Martin Duntiz;

Bhaskar M, Madhuri E, Abdul Latheef SAInfluence of zinc

on cardiac and serum biochemical parameters in rabbits.

Indian J Exp,.(2010);39:1170–2.

Henzel JH, Holtmann B, Keitzer FW, DeWeese MS,. Trace

elements in atherosclerosis, efficacy of zinc medication as a

therapeutic modality. Int J Exp Pathol. (2009). 85:265–75.

Oster O, Dahm M, Oelert H, Prellwitz W. Concentrations

of some trace elements (Se, Zn, Mg, K) in blood and heart

tissue of patients with coronary heart disease.Clin Chem.

.(2008); 35: 851-6.

Hennig B, Toborek M, McClain CJ..Antiatherogenic

properties of zinc: implications in endothelial cell


Duchateau J, Delepesse G, Vrijens R, Collet HBeneficial

effects of oral zinc supplementation on the immune

response of old people. Am J Med.(2008);70:1001–4.

Salonen J.T.S et al. Selenium and cancer : some nutritional

aspects. Am.J.Cardiol. (2010).56: 226-23117

Rotruck, J . T. , Pope, A .L., Ganther, H.E., Swason, A.B.

Selenium: biochemical role as a component of glutathione

peroxide. Science. ., (2007) 179:588—590.

Li y, Wang L, Schuschke DA, Zhou Z, Saari J, Kang

Y..Marginal dietary copper restriction induces

cardiomyopathy in animals. J Nut .(2009)135:2130-6.

Turski ML, Thiele DJ, Drosophila Ctr1A.Functions as a

copper transporter essential for development. Biol Chem;

.(2007). 282(33):2417-26.

Klevay LM. Heart failure improvement from a supplement

containing copper. Eur Heart J(2010).;27(1):117-8.

Allen KG, Klevay LM. Copper: an antioxidant nutrient for

cardiovascular health.Curr Opin Lipid (2009).;5:22-8.

Dunlap WM, James GW, Hume DM. Anemia and

neutropenia caused by copper deficiency. Am Inter Med


Anderson RA, Cheng N, et al. Elevated intake of

supplemental chromium improve glucose and insulin

variables in individuals with type 2 diabetes.Diabetics;


Roeback JR, HIa KM, Chambless LE, et al.Effect of

chromium supplementation on serum highdensity

lipoprotein cholesterol levels in men taking betablockers.

A randomized, controlled trial. AnnIntern. Med.

(2009);115:917—924 .

Lee N.A. Resamer CA. Beneficial effect of chromium

supplementation on serum triglyceride level in NIDDM

diabetes care`. (2010)`; 17: 1449—1452.

Uster , O. And Prellwitz W.,.The trace elements in heart

disease, J.Nutr. (2008) 130:4835—4845.

Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J,

, High stored iron levels are associated with excess

risk of myocardial infarction in eastern Finnish men.

Circulation(2010). ;86:803–811.

Buczynski A, Wachowicz B, Kedziora-Kornatowska K,

Tkaczewski W, Changes in antioxidant enzymes activities,

aggregability and malonyldialdehyde concentration in

bloodplatelets from patients with coronary heart disease.

Atherosclerosis; (2009)100:223-228.

David AM, James AL, Marc SS, Elliott MA. The Search

for a Biomarker of Cardiac Ischemia , Clinical Chemistry;


Griendling KK, Garret AF.Oxidative Stress and.

Cardiovascular Injury- Part II: Animal and Human Studies.

Circulation; (2006).108:2034-2040

DOI: http://dx.doi.org/10.26477/idj.v36i3.21


  • There are currently no refbacks.


Copyright by Iraqi Dental Journal

ISSN (Print): 2307-4779 | ISSN (Online): 2411-9741